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Lipodermatosclerosis

MedGen UID:
140802
•Concept ID:
C0406500
•
Disease or Syndrome
Synonyms: Acute lipodermatosclerosis; Hypodermitis sclerodermaformis; Sclerosing panniculitis
SNOMED CT: Lipodermatosclerosis (410016009)
 
Monarch Initiative: MONDO:0023646

Definition

A decrease in lower leg circumference due to recurrent ulceration and fat necrosis causing loss of subcutaneous tissue in a patient with venous stasis disease. [from SNOMEDCT_US]

Professional guidelines

PubMed

Post-treatment course of acute lipodermatosclerosis.
Suehiro K, Morikage N, Harada T, Takeuchi Y, Mizoguchi T, Ike S, Otuska R, Kurazumi H, Suzuki R, Hamano K
Phlebology 2023 Mar;38(2):73-79. Epub 2022 Dec 18 doi: 10.1177/02683555221147473. PMID: 36529929
Specific management of lipodermatosclerosis (sclerotic hypodermitis) in acute and chronic phase.
Klejtman T, Lazareth I, Yannoutsos A, Priollet P
J Med Vasc 2022 Oct;47(4):186-190. Epub 2022 Oct 28 doi: 10.1016/j.jdmv.2022.10.006. PMID: 36344029
Venous Ulcers: Diagnosis and Treatment.
Bonkemeyer Millan S, Gan R, Townsend PE
Am Fam Physician 2019 Sep 1;100(5):298-305. PMID: 31478635

Recent clinical studies

Etiology

Injection sclerotherapy for varicose veins.
de Ávila Oliveira R, Riera R, Vasconcelos V, Baptista-Silva JC
Cochrane Database Syst Rev 2021 Dec 10;12(12):CD001732. doi: 10.1002/14651858.CD001732.pub3. PMID: 34883526Free PMC Article
Venous Ulcers: Diagnosis and Treatment.
Bonkemeyer Millan S, Gan R, Townsend PE
Am Fam Physician 2019 Sep 1;100(5):298-305. PMID: 31478635
Standards for recanalisation of chronic venous outflow obstructions.
Lichtenberg M, de Graaf R, Erbel C
Vasa 2018 Jun;47(4):259-266. Epub 2018 Mar 8 doi: 10.1024/0301-1526/a000696. PMID: 29514591
The role of capsaicin in dermatology.
Boyd K, Shea SM, Patterson JW
Prog Drug Res 2014;68:293-306. doi: 10.1007/978-3-0348-0828-6_12. PMID: 24941674
Management of varicose veins and venous insufficiency.
Hamdan A
JAMA 2012 Dec 26;308(24):2612-21. doi: 10.1001/jama.2012.111352. PMID: 23268520

Diagnosis

Post-treatment course of acute lipodermatosclerosis.
Suehiro K, Morikage N, Harada T, Takeuchi Y, Mizoguchi T, Ike S, Otuska R, Kurazumi H, Suzuki R, Hamano K
Phlebology 2023 Mar;38(2):73-79. Epub 2022 Dec 18 doi: 10.1177/02683555221147473. PMID: 36529929
Venous Ulcers: Diagnosis and Treatment.
Bonkemeyer Millan S, Gan R, Townsend PE
Am Fam Physician 2019 Sep 1;100(5):298-305. PMID: 31478635
Panniculitis: A summary.
Wick MR
Semin Diagn Pathol 2017 May;34(3):261-272. Epub 2016 Dec 27 doi: 10.1053/j.semdp.2016.12.004. PMID: 28129926
Bilateral cellulitis.
Batra V, Baras A
BMJ Case Rep 2015 Sep 21;2015 doi: 10.1136/bcr-2015-211117. PMID: 26392449Free PMC Article
Distinguishing cellulitis from its mimics.
Keller EC, Tomecki KJ, Alraies MC
Cleve Clin J Med 2012 Aug;79(8):547-52. doi: 10.3949/ccjm.79a.11121. PMID: 22854433

Therapy

Injection sclerotherapy for varicose veins.
de Ávila Oliveira R, Riera R, Vasconcelos V, Baptista-Silva JC
Cochrane Database Syst Rev 2021 Dec 10;12(12):CD001732. doi: 10.1002/14651858.CD001732.pub3. PMID: 34883526Free PMC Article
Bilateral cellulitis.
Batra V, Baras A
BMJ Case Rep 2015 Sep 21;2015 doi: 10.1136/bcr-2015-211117. PMID: 26392449Free PMC Article
The role of capsaicin in dermatology.
Boyd K, Shea SM, Patterson JW
Prog Drug Res 2014;68:293-306. doi: 10.1007/978-3-0348-0828-6_12. PMID: 24941674
Venous eczema and lipodermatosclerosis.
Morton LM, Phillips TJ
Semin Cutan Med Surg 2013 Sep;32(3):169-76. doi: 10.12788/j.sder.0026. PMID: 24175404
Lipodermatosclerosis.
Miteva M, Romanelli P, Kirsner RS
Dermatol Ther 2010 Jul-Aug;23(4):375-88. doi: 10.1111/j.1529-8019.2010.01338.x. PMID: 20666825

Prognosis

Post-treatment course of acute lipodermatosclerosis.
Suehiro K, Morikage N, Harada T, Takeuchi Y, Mizoguchi T, Ike S, Otuska R, Kurazumi H, Suzuki R, Hamano K
Phlebology 2023 Mar;38(2):73-79. Epub 2022 Dec 18 doi: 10.1177/02683555221147473. PMID: 36529929
Venous Ulcers: Diagnosis and Treatment.
Bonkemeyer Millan S, Gan R, Townsend PE
Am Fam Physician 2019 Sep 1;100(5):298-305. PMID: 31478635
Standards for recanalisation of chronic venous outflow obstructions.
Lichtenberg M, de Graaf R, Erbel C
Vasa 2018 Jun;47(4):259-266. Epub 2018 Mar 8 doi: 10.1024/0301-1526/a000696. PMID: 29514591
Management of varicose veins and venous insufficiency.
Hamdan A
JAMA 2012 Dec 26;308(24):2612-21. doi: 10.1001/jama.2012.111352. PMID: 23268520
The clinical spectrum of lipodermatosclerosis.
Kirsner RS, Pardes JB, Eaglstein WH, Falanga V
J Am Acad Dermatol 1993 Apr;28(4):623-7. doi: 10.1016/0190-9622(93)70085-8. PMID: 8463465

Clinical prediction guides

Xioglican Cream in Italian Patients with Chronic Venous Disease: A Post-Marketing Study Investigating Effects on Clinical and Cutaneous Signs and Symptoms.
Muratori IM, Contorno F, Amato C
Adv Ther 2023 Nov;40(11):4972-4986. Epub 2023 Sep 19 doi: 10.1007/s12325-023-02665-0. PMID: 37725307Free PMC Article
Subcutaneous calcifications in legs with chronic venous diseases.
Caggiati A, Mosti G
J Vasc Surg Venous Lymphat Disord 2022 May;10(3):689-696. Epub 2022 Feb 23 doi: 10.1016/j.jvsv.2022.02.008. PMID: 35217216
Injection sclerotherapy for varicose veins.
de Ávila Oliveira R, Riera R, Vasconcelos V, Baptista-Silva JC
Cochrane Database Syst Rev 2021 Dec 10;12(12):CD001732. doi: 10.1002/14651858.CD001732.pub3. PMID: 34883526Free PMC Article
Standards for recanalisation of chronic venous outflow obstructions.
Lichtenberg M, de Graaf R, Erbel C
Vasa 2018 Jun;47(4):259-266. Epub 2018 Mar 8 doi: 10.1024/0301-1526/a000696. PMID: 29514591
Microvascular changes in chronic venous insufficiency--a review.
Leu AJ, Leu HJ, Franzeck UK, Bollinger A
Cardiovasc Surg 1995 Jun;3(3):237-45. doi: 10.1016/0967-2109(95)93871-l. PMID: 7655836

Recent systematic reviews

Injection sclerotherapy for varicose veins.
de Ávila Oliveira R, Riera R, Vasconcelos V, Baptista-Silva JC
Cochrane Database Syst Rev 2021 Dec 10;12(12):CD001732. doi: 10.1002/14651858.CD001732.pub3. PMID: 34883526Free PMC Article
Genetic polymorphisms of vein wall remodeling in chronic venous disease: a narrative and systematic review.
Bharath V, Kahn SR, Lazo-Langner A
Blood 2014 Aug 21;124(8):1242-50. Epub 2014 Jul 8 doi: 10.1182/blood-2014-03-558478. PMID: 25006132

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